Ochratoxin A (OTA) is a secondary metabolite of moulds belonging to the genera of Aspergillus and Penicillium, and its occurrence is common in poultry feed. As an effect of OTA, it is known that it causes oxidative stress in the animal body, causing lipid peroxidation, which affects the biological antioxidant system. Selenium is an essential element that plays an important role in antioxidant protection, so it can have an effect in mitigating and/or preventing the toxic effects caused by OTA. An in vivo study was performed in 21-day-old broiler chickens in a short-term (5-day) feeding trial with 2 mg/kg OTA, using selenium supplementation in two doses: 0.3 mg/kg, 0.5 mg/kg. We measured the markers of the glutathione system in the blood with biochemical methods: the amount of reduced glutathione, the activity of glutathione peroxidase and the concentration of malondialdehyde. Based on our results, significant differences were observed in the amount and activity of the elements of the glutathione system compared to the untreated group, which could be caused by oxidative stress, which was influenced by selenium supplementation.

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